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Anti-FANCM [M40-P2C6]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 151876
Applications ELISA IF WB
Antigen/Gene or Protein Targets Fanconi Anemia, Complementation Group M (FANC-M)
Synonyms Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 250 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP250
Reactivity Human
Relevance Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.
Host Mouse
Immunogen Peptide Sequence - MLPNDLNQDR (amino acids 2069 -2078)
Subclass IgG1 kappa
Positive Control ELISA- Peptide immunogenWestern Blot- Hela membrane cell extractIF- Hela cells
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM + 60 ml Fetal Bovine Serum plus 3ml L-Glutamine + 3ml of Penicillin -Streptomycin.
Strain Balb/c
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

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