Anti-FANCM [M40-P2C6]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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| Catalogue Number | 151876 |
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | Fanconi Anemia, Complementation Group M (FANC-M) |
| Synonyms | Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 250 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP250 |
| Reactivity | Human |
| Relevance | Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk. |
| Host | Mouse |
| Immunogen | Peptide Sequence - MLPNDLNQDR (amino acids 2069 -2078) |
| Positive Control | ELISA- Peptide immunogenWestern Blot- Hela membrane cell extractIF- Hela cells |
| Subclass | IgG1 kappa |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM + 60 ml Fetal Bovine Serum plus 3ml L-Glutamine + 3ml of Penicillin -Streptomycin. |
| Strain | Balb/c |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
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