Anti-Cytochrome P450 4F11 [F21 P6 F5]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
- References (8)
- Inventor Info
Info
![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded normal and primary colorectal tumour tissue sections using neat culture supernatants of anti-CYP4F11 [F21 P6 F5]. The photomicrographs show much stronger immunostaining of in primary colorectal tumour compared to normal colon mucosa. Cytoplasmic localisation of CYP4F11 is also observed.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/5ef86eda-0fe8-480a-9edc-b142b0600bdb.jpg)
![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded normal and primary colorectal tumour tissue sections using neat culture supernatants of anti-CYP4F11 [F21 P6 F5]. The photomicrographs show much stronger immunostaining of in primary colorectal tumour compared to normal colon mucosa. Cytoplasmic localisation of CYP4F11 is also observed.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/5ef86eda-0fe8-480a-9edc-b142b0600bdb.jpg)
![Image thumbnail for Anti-Cytochrome P450 4F11 [F21 P6 F5]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/1b825ca1-a90e-49ca-acd8-0ac2dbc1f98e.jpg)
![Image thumbnail for Anti-Cytochrome P450 4F11 [F21 P6 F5]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/42497824-2a09-4541-a510-9a94027b517d.jpg)
![Image thumbnail for Anti-Cytochrome P450 4F11 [F21 P6 F5]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/5ef86eda-0fe8-480a-9edc-b142b0600bdb.jpg)
| Catalogue Number | 151865 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | CYP4F11- Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11) |
| Reactivity | Human |
| Relevance | Cytochrome P450 4F11 (CYP4F11) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4F11 has catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs, including benzphetamine, ethylmorphine, chlorpromazine, imipramine and erythromycin. CYP4F11 is expressed in the liver, kidney, heart, brain, and skeletal muscle and is overexpressed in ovarian and colon cancers. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide RVEPLGANSQ (C-terminal sequence) |
| Positive Control | IHC: formalin-fixed, paraffin-embedded liposarcoma sections. western blot: kidney cell lysates |
| Subclass | IgG1 kappa |
| Strain | Balb/c |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
References: 8 entries
Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.
The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.
Europe PMC ID: 28557975
Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872
IHC
Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016.
Europe PMC ID: 27747872
Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Europe PMC ID: 16243809
Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Europe PMC ID: 15897573
Add a reference
References: 8 entries
Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.
The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.
Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872
IHC
Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016.
Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.
Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Add a reference
