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Anti-Cytochrome P450 4F11 [F21 P6 F5]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 151865
Applications ELISA IHC WB
Antigen/Gene or Protein Targets CYP4F11- Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11)
Reactivity Human
Relevance Cytochrome P450 4F11 (CYP4F11) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4F11 has catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs, including benzphetamine, ethylmorphine, chlorpromazine, imipramine and erythromycin. CYP4F11 is expressed in the liver, kidney, heart, brain, and skeletal muscle and is overexpressed in ovarian and colon cancers.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide RVEPLGANSQ (C-terminal sequence)
Subclass IgG1 kappa
Positive Control IHC: formalin-fixed, paraffin-embedded liposarcoma sections. western blot: kidney cell lysates
Strain Balb/c
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References: 8 entries

Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.

The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.

Europe PMC ID: 28557975

Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872

IHC

Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016.

Europe PMC ID: 27747872

Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.

Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.

Europe PMC ID: 16243809

Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.

Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.

Europe PMC ID: 15897573


Add a reference

References: 8 entries

Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.

The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.

Europe PMC ID: 28557975

Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872

IHC

Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016.

Europe PMC ID: 27747872

Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.

Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.

Europe PMC ID: 16243809

Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.

Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.

Europe PMC ID: 15897573


Add a reference

References: 8 entries

Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.

The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.

Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872

IHC

Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016.

Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.

Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.

Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.

Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.


Add a reference


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