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Catalogue Number 151841
Applications IF IP WB
Antigen/Gene or Protein Targets NSun2 (Misu)
Reactivity Human
Relevance NSun2 is a cytosine-5 RNA methyltransferase of transfer RNAs (tRNAs) and other non-coding RNAs. NSun2 is expressed in various tissues, including skin, brain and testis. Expression of Nsun2 is up-regulated in many tumours.
Host Rabbit
Immunogen NSun2 (Misu) peptides conjugated with keyhole limpet hemocyanin
Formulation Whole serum
Molecular Weight (kDa) 80
Notes Alternative Polyclonal Name: hMetA

Other Research Area: Post-transcriptional modifying enzyme

Note on MW: Mw should be around 80kDa but the band runs around 100kDa in a western

Staining Pattern: Nuclear, mainly in the nucleolus in interphase and at the spindel in M-phase of the cell cycle

Suggested Dilutions: IF: 1:1000; WB: 1:1000; IHC: 1:250
Positive Control Human keratinocytes, human breast cancer cell lines
Research Area Epigenetics & Nuclear Signalling
Immunogen UniProt ID N/A

References

There are 6 reference entries for this reagent.

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References: 6 entries

Frye et al. 2010. Cancer Lett. 289(1):71-80. PMID: 19740597.

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.

Europe PMC ID: 19740597

Hussain et al. 2009. J Cell Biol. 186(1):27-40. PMID: 19596847.

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.

Europe PMC ID: 19596847

Frye et al. 2006. Curr Biol. 16(10):971-81. PMID: 16713953.

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.

Europe PMC ID: 16713953


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References: 6 entries

Frye et al. 2010. Cancer Lett. 289(1):71-80. PMID: 19740597.

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.

Hussain et al. 2009. J Cell Biol. 186(1):27-40. PMID: 19596847.

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability.

Frye et al. 2006. Curr Biol. 16(10):971-81. PMID: 16713953.

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.


Add a reference

Inventor Information