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Anti-TIMP2 [3A4]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 151837
Applications ELISA IHC WB
Antigen/Gene or Protein Targets TIMP2 (tissue inhibitor of metalloproteinases 2)
Reactivity Human, Mouse, Rat and Zebrafish
Relevance Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis.

Expression of TIMP2 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; DSGNDIYGNPI
Subclass IgG2b
Positive Control IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma Western blot: rhTIMP-2, 400 ng per lane
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing L-Glutamine and 20% Fetal Bovine serum (DH20) .
Strain Balb/c
Notes (i) no cross-reactivity with TIMP-1 in immunoblot, (ii) staining in antigen-positive wax-imbedded tissues
Research Area Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Protein Degradation

References: 5 entries

Keren-Shaul et al. 2017. Cell. 169(7):1276-1290.e17. PMID: 28602351.

IHC

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.


Add a reference

References: 5 entries

Keren-Shaul et al. 2017. Cell. 169(7):1276-1290.e17. PMID: 28602351.

IHC

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.


Add a reference

References: 5 entries

Keren-Shaul et al. 2017. Cell. 169(7):1276-1290.e17. PMID: 28602351.

IHC

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.


Add a reference


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