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HRN Nude Mouse

Invented by Prof Roland Wolf at University of Dundee, Dr Colin Henderson at University of Dundee

Info

Catalogue Number 151829
Antigen/Gene or Protein Targets P450 Oxidoreductase
Relevance A P450 Oxidoreductase hepatic null in nude background (ICRF nude mouse). This mouse has a conditional deletion of POR and may be used in the drug development process to establish role of P450 activity in anti-cancer drug efficacy in vivo.
Production Details The hepatic reductase null (HRN) line, which is PORlox/lox::CreALB, was crossed to the ICRF nude mouse. The ultimate experimental mouse is thus PORlox/lox::CreALB::nu/nu, with PORlox/lox::nu/nu as matched controls (the latter are essentially 'ordinary' nude mice, with normal POR expression, and thus normal hepatic P450 activity).
Conditional Yes
Mouse Genetic Background/Cross History Mixture of C57BL/6J (HRN background) and the ICRF nude mouse.
Research Area Cancer, Drug Discovery & Development, Genetic Studies Tools, Metabolism

References: 2 entries

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Europe PMC ID: 12566435


Add a reference

References: 2 entries

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Europe PMC ID: 12566435


Add a reference

References: 2 entries

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.


Add a reference


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