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Anti-PITPb [1C1]

Info

Catalogue Number 151820
Applications ELISA IF WB
Antigen/Gene or Protein Targets Rat PITPb
Reactivity Human, Mouse, Rat and Dog
Relevance Mammalian PITPß (phosphatidylinositol transfer protein ß) is a 272-amino-acid polypeptide capable of transferring PtdIns, PtdCho and SM (sphingomyelin) between membrane bilayers. Ablation of PITPß is embryonically lethal. This antibody is specific for both splice variants of PITPß but does not recognise PITPa despite the 95% similarity between the two.
Host Mouse
Immunogen Whole Rat PITPb protein
Subclass IgG
Recommended Growing Conditions RPMI 1640 + 10% FCS + 2mM L-glutamine + penicillin/streptomycin
Notes Antibody specific for both splice variants of PITPb but does not recognise PITPa.

Production yield is high

Does work in IF but not as good as DaRT/U/4a7
Research Area Cell Signaling & Signal Transduction

References: 6 entries

Carvou et al. 2010. J Cell Sci. 123(Pt 8):1262-73. PMID: 20332109.

Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum.

Europe PMC ID: 20332109

Shadan et al. 2008. Traffic. 9(10):1743-56. PMID: 18636990.

Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.

Europe PMC ID: 18636990

Morgan et al. 2006. Biochem J. 398(3):411-21. PMID: 16780419.

Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.

Europe PMC ID: 16780419


Add a reference

References: 6 entries

Carvou et al. 2010. J Cell Sci. 123(Pt 8):1262-73. PMID: 20332109.

Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum.

Europe PMC ID: 20332109

Shadan et al. 2008. Traffic. 9(10):1743-56. PMID: 18636990.

Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.

Europe PMC ID: 18636990

Morgan et al. 2006. Biochem J. 398(3):411-21. PMID: 16780419.

Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.

Europe PMC ID: 16780419


Add a reference

References: 6 entries

Carvou et al. 2010. J Cell Sci. 123(Pt 8):1262-73. PMID: 20332109.

Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum.

Shadan et al. 2008. Traffic. 9(10):1743-56. PMID: 18636990.

Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.

Morgan et al. 2006. Biochem J. 398(3):411-21. PMID: 16780419.

Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.


Add a reference


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