Anti-CD22 [To15]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151792 |
| Applications | FACS |
| Antigen/Gene or Protein Targets | CD22 |
| Reactivity | Human |
| Relevance | SIGLEC-2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias. |
| Host | Mouse |
| Immunogen | Tonsil cells |
| Subclass | IgG2b kappa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT. Ultroser G (**) can be used at 1% if the cells are not growing well.Please note that this cell line has not been weaned out of HAT. |
| Research Area | Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
References: 2 entries
Mason et al. 1987. Blood. 69(3):836-40. PMID: 3101766.
Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells.
Europe PMC ID: 3101766
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References: 2 entries
Mason et al. 1987. Blood. 69(3):836-40. PMID: 3101766.
Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells.
Add a reference
