Anti-CD11C [118/A5]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151790 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX |
| Reactivity | Human |
| Relevance | The integrin alpha X chain protein (CD11c) belongs to the ß2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ß subunit. CD11c (the a subunit) combines with CD18 (the ß subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow. |
| Host | Mouse |
| Immunogen | Synthetic peptide conjugated to KLH corresponding to the C terminus of human CD11C: ANGQIAPENGTQTPSPPSEK |
| Positive Control | Human tonsil |
| Subclass | IgG2b |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Research Area | Adhesion, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
References: 8 entries
Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175.
Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.
Europe PMC ID: 16985175
Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059.
Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.
Europe PMC ID: 10929059
Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600.
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
Europe PMC ID: 7512600
Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921.
Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.
Europe PMC ID: 2969921
Add a reference
References: 8 entries
Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175.
Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.
Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059.
Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.
Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600.
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921.
Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.
Add a reference
