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Anti-CD11C [118/A5]

Invented by Dr Jacqueline Cordell at University of Oxford

Info

Catalogue Number 151790
Applications IHC
Antigen/Gene or Protein Targets CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX
Reactivity Human
Relevance The integrin alpha X chain protein (CD11c) belongs to the ß2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ß subunit. CD11c (the a subunit) combines with CD18 (the ß subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.
Host Mouse
Immunogen Synthetic peptide conjugated to KLH corresponding to the C terminus of human CD11C: ANGQIAPENGTQTPSPPSEK
Subclass IgG2b
Positive Control Human tonsil
Myeloma Used NS0
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Research Area Adhesion, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 8 entries

Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175.

Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.

Europe PMC ID: 16985175

Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059.

Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.

Europe PMC ID: 10929059

Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600.

The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.

Europe PMC ID: 7512600

Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921.

Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.

Europe PMC ID: 2969921


Add a reference

References: 8 entries

Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175.

Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.

Europe PMC ID: 16985175

Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059.

Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.

Europe PMC ID: 10929059

Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600.

The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.

Europe PMC ID: 7512600

Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921.

Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.

Europe PMC ID: 2969921


Add a reference

References: 8 entries

Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175.

Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.

Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059.

Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.

Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600.

The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.

Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921.

Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.


Add a reference


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