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Anti-PDGFR alpha [PDGFR-H7A]

Invented by Dr Jacqueline Cordell at University of Oxford

Info

Catalogue Number 151787
Applications IP
Antigen/Gene or Protein Targets PDGFR alpha, platelet-derived growth factor receptor, alpha polypeptide.
Reactivity Human
Relevance This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Host Mouse
Immunogen Recombinant protein corresponding to amino acids 1 to 78 of human PDGFRA
Subclass IgG1
Positive Control Human Hela cell line
Myeloma Used NS0
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Research Area Cancer

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