Anti-PDGFR alpha [PDGFR-H7A]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
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Info
| Catalogue Number | 151787 |
| Applications | IP |
| Antigen/Gene or Protein Targets | PDGFR alpha, platelet-derived growth factor receptor, alpha polypeptide. |
| Reactivity | Human |
| Relevance | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. |
| Host | Mouse |
| Immunogen | Recombinant protein corresponding to amino acids 1 to 78 of human PDGFRA |
| Positive Control | Human Hela cell line |
| Subclass | IgG1 lambda |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Research Area | Cancer |
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