Anti-FMIP [F6D/11]
Invented by Prof Alison Banham from University of Oxford
Invented at University of Oxford
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151786 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Fms interacting protein (FMIP) |
| Reactivity | Human |
| Relevance | Fms interacting protein (FMIP) is a substrate, as well as a binding partner, of Fms tyrosine kinase. FMIP is a ubiquitous nuclear/cytoplasm shuttling protein with a leucine zipper. The overexpression of FMIP in myeloid progenitor cells alters the macrophage colony stimulating factor (M-CSF)-mediated macrophage differentiation. These cells differentiate into the granulocytic lineage rather than into the macrophage lineage. Furthermore, it has been shown that FMIP is one of the major molecules phosphorylated via the insulin-mediated signaling pathway in a preadipocyte cell line, 3T3-L1 cells, suggesting that FMIP may play a role in adipocyte differentiation. |
| Host | Mouse |
| Immunogen | C-terminus of the human FMIP protein as a glutathione-S-transferase (GST) fusion protein |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 supplemented with 10% FBS, L-glutamine, Ultroser G and HAT. Please note that they have not been weaned off HAT and will not grow without it. |
| Research Area | Cell Signaling & Signal Transduction, Cell Structure and Motility, Immunology |
References: 6 entries
Guria et al. 2011. RNA. 17(6):1048-56. PMID: 21525145.
WB
Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.
Europe PMC ID: 21525145
Mancini et al. 2010. BMC Biol. 8:1. PMID: 20051105.
IHC
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Europe PMC ID: 20051105
Mancini et al. 2007. Oncogene. 26(7):1020-7. PMID: 16909111.
IHC WB
FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
Europe PMC ID: 16909111
Add a reference
References: 6 entries
Guria et al. 2011. RNA. 17(6):1048-56. PMID: 21525145.
WB
Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.
Mancini et al. 2010. BMC Biol. 8:1. PMID: 20051105.
IHC
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Mancini et al. 2007. Oncogene. 26(7):1020-7. PMID: 16909111.
IHC WB
FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
Add a reference
