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MCF7aro Let-R Cell Line

Info

Catalogue Number 151781
Antigen/Gene or Protein Targets Aromatase expressing, Letrozole resistant
Parental Line MCF7
Host Human
Tissue Breast
Disease Keywords Breast cancer
Model Tumour line
Relevance MCF7aro Let-R Cell Line is a human cell line model of aromatase inhibitor resistant breast cancer.
Production Details Letrozole (aromatase inhibitor) sensitive cells (MCF-7aro) were developed by stable transfection of the aromatase gene (CYP19); Letrozole-resistant cells (MCF-7aro Let-R) were created by long-term treatment of aromatase-expressing MCF7 cells (MCF7aro) with letrozole.
Research Area Cancer, Drug Discovery & Development
Recommended Growing Conditions MCF7aroLetR are maintained in phenol red-free MEM, supplemented with Charcoal Dextran Stripped-Foetal Calf Serum (10%), L-glutamine (1%), penicillin/streptomycin(1%), G-418 (800µg/ml), androstenedione (25nM; SigmaAldrich) and letrozole(1µM; Novartis)
Cellosaurus ID CVCL_W348

References: 5 entries

Cellosaurus MCF-7aro Let-R (CVCL_W348)

O'Hara et al. 2012. Clin Cancer Res. 18(12):3305-15. PMID: 22550166.

AIB1:ERα transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast cancer cells.

Europe PMC ID: 22550166

McIlroy et al. 2010. Cancer Res. 70(4):1585-94. PMID: 20145129.

Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].

Europe PMC ID: 20145129


Add a reference

References: 5 entries

Cellosaurus MCF-7aro Let-R (CVCL_W348)

O'Hara et al. 2012. Clin Cancer Res. 18(12):3305-15. PMID: 22550166.

AIB1:ERα transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast cancer cells.

Europe PMC ID: 22550166

McIlroy et al. 2010. Cancer Res. 70(4):1585-94. PMID: 20145129.

Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].

Europe PMC ID: 20145129


Add a reference

References: 5 entries

Cellosaurus MCF-7aro Let-R (CVCL_W348)

O'Hara et al. 2012. Clin Cancer Res. 18(12):3305-15. PMID: 22550166.

AIB1:ERα transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast cancer cells.

McIlroy et al. 2010. Cancer Res. 70(4):1585-94. PMID: 20145129.

Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected].


Add a reference


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