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HBRN Mouse

Invented by Dr Colin Henderson at University of Dundee, Prof Roland Wolf at University of Dundee

Info

Catalogue Number 151773
Antigen/Gene or Protein Targets P450, Cyb5
Relevance Improved model of abrogation of hepatic P450 function. The dual deletion of both Cyb5 and POR almost completely abrogates all hepatic cytochrome P450 activities; the new HBRN model thus provides a more authentic hepatic-P450 null phenotype
Production Details HBRN (Cytb5lox/lox::PORlox/lox ± CreALB) and wild-type (WT; PORlox/lox::Cyb5lox/lox) were generated by crossing HRN (PORlox/lox + CreALB ) and floxed cytochrome b5 mice (Cytb5lox/lox), and thereafter maintained by crossing of homozygous pairs within each line.
Conditional No
Mouse Genetic Background/Cross History C57BL/6J
Zygosity HBRN (Cytb5lox/lox::PORlox/lox ± CreALB)
Research Area Cell Signaling & Signal Transduction, DNA Damage and Repair, Genetic Studies Tools, Metabolism

References: 4 entries

Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.

Europe PMC ID: 23530090

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Europe PMC ID: 12566435


Add a reference

References: 4 entries

Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.

Europe PMC ID: 23530090

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Europe PMC ID: 12566435


Add a reference

References: 4 entries

Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.


Add a reference


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