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HBRN Mouse

Invented by Dr Colin Henderson at University of Dundee, Prof Roland Wolf at University of Dundee

Info

Catalogue Number 151773
Antigen/Gene or Protein Targets P450, Cyb5
Relevance Improved model of abrogation of hepatic P450 function. The dual deletion of both Cyb5 and POR almost completely abrogates all hepatic cytochrome P450 activities; the new HBRN model thus provides a more authentic hepatic-P450 null phenotype
Production Details HBRN (Cytb5lox/lox::PORlox/lox ± CreALB) and wild-type (WT; PORlox/lox::Cyb5lox/lox) were generated by crossing HRN (PORlox/lox + CreALB ) and floxed cytochrome b5 mice (Cytb5lox/lox), and thereafter maintained by crossing of homozygous pairs within each line.
Conditional No
Mouse Genetic Background/Cross History C57BL/6J
Zygosity HBRN (Cytb5lox/lox::PORlox/lox ± CreALB)
Research Area Cell Signaling & Signal Transduction, DNA Damage and Repair, Genetic Studies Tools, Metabolism

References: 2 entries

Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.


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References: 2 entries

Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.


Add a reference

References: 2 entries

Henderson et al. 2013. Mol Pharmacol. 83(6):1209-17. PMID: 23530090.

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.


Add a reference


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