Anti-MCM5 [A2.9B4.B12.D8.B8]
Invented at University of Cambridge
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Info
| Catalogue Number | 151764 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Mini Chromosome Maintenance protein5 (MCM5) |
| Synonyms | Minichromosome Maintenance Complex Component 5; P1-CDC46; CDC46; Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46); EC 3.6.4.12 |
| Reactivity | Human |
| Relevance | MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal. |
| Host | Mouse |
| Immunogen | His-tagged human Mcm5 (amino acids 367–582) |
| Subclass | IgG2b |
| Recommended Growing Conditions | 20% OPI Serum |
| Notes |
Alternative names: 352.9B4 Nuclear/cytoplasmic staining is observed with this antibody using immunofluorescence |
| Research Area | Epigenetics & Nuclear Signalling |
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