Anti-BCL11A [BCL11A/123]
Invented by Prof Alison Banham from University of Oxford
Invented at University of Oxford
- Datasheet
- References (10)
- Inventor Info
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| Catalogue Number | 151750 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | BCL11A (EVI9, CTIP1) |
| Reactivity | Human and Rat |
| Relevance | BCL11A is a Krüppel zinc-finger transcription factor that was identified originally from a chromosome translocation in aggressive B-cell chronic lymphocytic leukaemia. The gene may function as both an oncogene and a tumour suppressor. Alternative splicing generates multiple isoforms, the BCL11AXL being the largest and most abundant transcript. The protein is differentially expressed during B-cell development and is strongly expressed in plasmacytoid dendritic cells. The BCL11A/123 antibody specifically recognises the extra long form of the protein and not the long or short forms of BCL11A. The BCL11A/123 antibody is not cross reactive with the long form of the BCL11B protein that shares significant sequence identity with the immunogen. |
| Host | Mouse |
| Immunogen | C-terminus of extra long isoform of BCL11A, BCL11AXL (aa 637-835) |
| Positive Control | Tonsil (in B cells and plasmcytoid dendritic cells), Neurones and nuclei of some epithelium |
| Subclass | IgG1 |
| Molecular Weight (kDa) | Predicted 91KDa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Notes |
IHC: Frozen use neat supernatant IHC: Paraffin use 1/10 supernatant WB: use neat supernatant. |
| Research Area | Cancer, Epigenetics & Nuclear Signalling, Neurobiology |
References: 10 entries
Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.
Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.
Europe PMC ID: 19096012
Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.
Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
Europe PMC ID: 18218851
Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.
Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.
Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.
Europe PMC ID: 16871282
The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells.
Europe PMC ID: 16710303
Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.
Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.
Europe PMC ID: 16704730
Add a reference
References: 10 entries
Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.
Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.
Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.
Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.
Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.
Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.
The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells.
Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.
Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.
Add a reference
