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Anti-BCL11A [BCL11A/123]

Invented by Prof Alison Banham at University of Oxford

Info

Catalogue Number 151750
Applications IHC IP WB
Antigen/Gene or Protein Targets BCL11A (EVI9, CTIP1)
Reactivity Human and Rat
Relevance BCL11A is a Kr├╝ppel zinc-finger transcription factor that was identified originally from a chromosome translocation in aggressive B-cell chronic lymphocytic leukaemia. The gene may function as both an oncogene and a tumour suppressor. Alternative splicing generates multiple isoforms, the BCL11AXL being the largest and most abundant transcript. The protein is differentially expressed during B-cell development and is strongly expressed in plasmacytoid dendritic cells. The BCL11A/123 antibody specifically recognises the extra long form of the protein and not the long or short forms of BCL11A. The BCL11A/123 antibody is not cross reactive with the long form of the BCL11B protein that shares significant sequence identity with the immunogen.
Host Mouse
Immunogen C-terminus of extra long isoform of BCL11A, BCL11AXL (aa 637-835)
Subclass IgG1
Positive Control Tonsil (in B cells and plasmcytoid dendritic cells), Neurones and nuclei of some epithelium
Molecular Weight (kDa) Predicted 91KDa
Myeloma Used P3/NS1/1-Ag4.1
Notes IHC: Frozen use neat supernatant
IHC: Paraffin use 1/10 supernatant
WB: use neat supernatant.
Research Area Cancer, Epigenetics & Nuclear Signalling, Neurobiology

References: 5 entries

Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.

Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.

Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.

Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.

Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.


Add a reference

References: 5 entries

Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.

Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.

Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.

Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.

Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.


Add a reference

References: 5 entries

Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.

Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.

Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.

Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.

Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.


Add a reference


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