Log in Register
Menu

Anti-BCL11A [BCL11A/123]

Invented by Prof Alison Banham at University of Oxford

Info

Catalogue Number 151750
Applications IHC IP WB
Antigen/Gene or Protein Targets BCL11A (EVI9, CTIP1)
Reactivity Human and Rat
Relevance BCL11A is a Kr├╝ppel zinc-finger transcription factor that was identified originally from a chromosome translocation in aggressive B-cell chronic lymphocytic leukaemia. The gene may function as both an oncogene and a tumour suppressor. Alternative splicing generates multiple isoforms, the BCL11AXL being the largest and most abundant transcript. The protein is differentially expressed during B-cell development and is strongly expressed in plasmacytoid dendritic cells. The BCL11A/123 antibody specifically recognises the extra long form of the protein and not the long or short forms of BCL11A. The BCL11A/123 antibody is not cross reactive with the long form of the BCL11B protein that shares significant sequence identity with the immunogen.
Host Mouse
Immunogen C-terminus of extra long isoform of BCL11A, BCL11AXL (aa 637-835)
Subclass IgG1
Positive Control Tonsil (in B cells and plasmcytoid dendritic cells), Neurones and nuclei of some epithelium
Molecular Weight (kDa) Predicted 91KDa
Myeloma Used P3/NS1/1-Ag4.1
Notes IHC: Frozen use neat supernatant
IHC: Paraffin use 1/10 supernatant
WB: use neat supernatant.
Research Area Cancer, Epigenetics & Nuclear Signalling, Neurobiology

References: 10 entries

Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.

Europe PMC ID: 19096012

Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.

Novel markers of normal and neoplastic human plasmacytoid dendritic cells.

Europe PMC ID: 18218851

Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.

Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.

Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.

Europe PMC ID: 16871282

The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells.

Europe PMC ID: 16710303

Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.

Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.

Europe PMC ID: 16704730


Add a reference

References: 10 entries

Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.

Europe PMC ID: 19096012

Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.

Novel markers of normal and neoplastic human plasmacytoid dendritic cells.

Europe PMC ID: 18218851

Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.

Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.

Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.

Europe PMC ID: 16871282

The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells.

Europe PMC ID: 16710303

Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.

Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.

Europe PMC ID: 16704730


Add a reference

References: 10 entries

Chetaille et al. 2009. Blood. 113(12):2765-3775. PMID: 19096012.

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.

Marafioti et al. 2008. Blood. 111(7):3778-92. PMID: 18218851.

Novel markers of normal and neoplastic human plasmacytoid dendritic cells.

Weniger et al. 2006. Leukemia. 20(10):1880-2. PMID: 16871282.

Pulford et al. 2006. Leukemia. 20(8):1439-41. PMID: 16710303.

Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.

The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells.

Liu et al. 2006. Mol Cancer. 5:18. PMID: 16704730.

Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.


Add a reference


This reagent does not have any reviews at the moment.