Anti-MCM5 [A2.4B4.B7.A11.A8]
Invented at University of Cambridge
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151727 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Mini Chromosome Maintenance protein5 (MCM5) |
| Synonyms | Minichromosome Maintenance Complex Component 5; P1-CDC46; CDC46; Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46); EC 3.6.4.12 |
| Reactivity | Human |
| Relevance | MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal. |
| Host | Mouse |
| Immunogen | Bacterially expressed His-tagged human Mcm5 (amino acids 367-582) |
| Positive Control | HeLa, HL60 |
| Subclass | IgG2b |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | 20% OPI serum |
| Strain | Balb/c |
| Notes | Also known as: 352.4B4 or A2.4B4.B7.A11.A8 |
| Research Area | Epigenetics & Nuclear Signalling |
References: 2 entries
Stoeber et al. 2002. J Natl Cancer Inst. 94(14):1071-9. PMID: 12122098.
Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.
Europe PMC ID: 12122098
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References: 2 entries
Stoeber et al. 2002. J Natl Cancer Inst. 94(14):1071-9. PMID: 12122098.
Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.
Add a reference
