Anti-Cytochrome P450 3A4, Polyclonal [CYP3A4]
Invented by Prof Roland Wolf from University of Dundee
Invented at University of Dundee
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Info
| Catalogue Number | 151726 |
| Applications | WB |
| Antigen/Gene or Protein Targets | CYP 3A4 |
| Reactivity | Human |
| Relevance | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. |
| Host | Sheep |
| Immunogen | Purified recombinant human P450s |
| Positive Control | Human Liver Microsomes |
| Research Area | Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism |
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Inventor Information
Inventors
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Prof Roland Wolf |
