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Anti-Cytochrome P450 2E1, Polyclonal [CYP2E1]

Invented by Prof Roland Wolf at University of Dundee

Info

Catalogue Number 151725
Applications WB
Antigen/Gene or Protein Targets Cytochrome P450 2E1, CYP2E1
Reactivity Human
Relevance This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Host Sheep
Immunogen Purified recombinant human P450s
Positive Control Human Liver Microsomes
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism

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