Anti-Desmoglein 1 [32-2B]
Invented at University of Southampton
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 151720 |
| Applications | EM IHC IF WB |
| Antigen/Gene or Protein Targets | Desmoglein 1 |
| Synonyms | Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DGI, DSG, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1 |
| Reactivity | Bovine and Human |
| Relevance | Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are intercellular adhesive junctions that occur in almost all epithelia and should therefore be useful as epithelial markers in tumour diagnosis. This antibody was tested for its ability to stain epithelia and tumours. 32-2B is a reliable epithelial marker that may have a useful role in diagnostic histopathology. |
| Host | Mouse |
| Immunogen | Bovine desmoglein (desmosomal glycoprotein I) from nasal epidermis |
| Subclass | IgG2a kappa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 2mM glutamine + 20% Foetal Bovine Serum |
| Strain | Balb/c |
| Research Area | Adhesion, Cancer, Cell Signaling & Signal Transduction |
References: 10 entries
Maruani et al. 2008. Am J Clin Pathol. 130(3):369-74. PMID: 18701409.
IHC
Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome.
Europe PMC ID: 18701409
A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen.
Europe PMC ID: 7615689
Vilela et al. 1995. J Cell Sci. 108 ( Pt 4):1743-50. PMID: 7615689.
IF WB
Harada et al. 1992. Int J Oral Maxillofac Surg. 21(6):346-9. PMID: 1282923.
IHC
Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential.
Europe PMC ID: 1282923
Conn et al. 1990. Br J Urol. 65(2):176-80. PMID: 2317652.
IHC
Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein 1. Its role in the histological assessment of urothelial carcinomas.
Europe PMC ID: 2317652
Vilela et al. 1987. J Pathol. 153(4):365-75. PMID: 3323436.
IHC
Monoclonal antibody to desmosomal glycoprotein 1--a new epithelial marker for diagnostic pathology.
Europe PMC ID: 3323436
Add a reference
References: 10 entries
Maruani et al. 2008. Am J Clin Pathol. 130(3):369-74. PMID: 18701409.
IHC
Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome.
A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen.
Vilela et al. 1995. J Cell Sci. 108 ( Pt 4):1743-50. PMID: 7615689.
IF WB
Harada et al. 1992. Int J Oral Maxillofac Surg. 21(6):346-9. PMID: 1282923.
IHC
Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential.
Conn et al. 1990. Br J Urol. 65(2):176-80. PMID: 2317652.
IHC
Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein 1. Its role in the histological assessment of urothelial carcinomas.
Vilela et al. 1987. J Pathol. 153(4):365-75. PMID: 3323436.
IHC
Monoclonal antibody to desmosomal glycoprotein 1--a new epithelial marker for diagnostic pathology.
Add a reference
