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Anti-Desmoglein 1 [32-2B]

Info

Catalogue Number 151720
Applications EM IHC IF WB
Antigen/Gene or Protein Targets Desmoglein 1
Synonyms Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DGI, DSG, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1
Reactivity Bovine and Human
Relevance Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are intercellular adhesive junctions that occur in almost all epithelia and should therefore be useful as epithelial markers in tumour diagnosis. This antibody was tested for its ability to stain epithelia and tumours. 32-2B is a reliable epithelial marker that may have a useful role in diagnostic histopathology.
Host Mouse
Immunogen Bovine desmoglein (desmosomal glycoprotein I) from nasal epidermis
Subclass IgG2a
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 2mM glutamine + 20% Foetal Bovine Serum
Strain Balb/c
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction

References: 10 entries

Maruani et al. 2008. Am J Clin Pathol. 130(3):369-74. PMID: 18701409.

IHC

Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome.

Europe PMC ID: 18701409

A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen.

Europe PMC ID: 7615689

Vilela et al. 1995. J Cell Sci. 108 ( Pt 4):1743-50. PMID: 7615689.

IF WB

Harada et al. 1992. Int J Oral Maxillofac Surg. 21(6):346-9. PMID: 1282923.

IHC

Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential.

Europe PMC ID: 1282923

Conn et al. 1990. Br J Urol. 65(2):176-80. PMID: 2317652.

IHC

Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein 1. Its role in the histological assessment of urothelial carcinomas.

Europe PMC ID: 2317652

Vilela et al. 1987. J Pathol. 153(4):365-75. PMID: 3323436.

IHC

Monoclonal antibody to desmosomal glycoprotein 1--a new epithelial marker for diagnostic pathology.

Europe PMC ID: 3323436


Add a reference

References: 10 entries

Maruani et al. 2008. Am J Clin Pathol. 130(3):369-74. PMID: 18701409.

IHC

Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome.

Europe PMC ID: 18701409

A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen.

Europe PMC ID: 7615689

Vilela et al. 1995. J Cell Sci. 108 ( Pt 4):1743-50. PMID: 7615689.

IF WB

Harada et al. 1992. Int J Oral Maxillofac Surg. 21(6):346-9. PMID: 1282923.

IHC

Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential.

Europe PMC ID: 1282923

Conn et al. 1990. Br J Urol. 65(2):176-80. PMID: 2317652.

IHC

Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein 1. Its role in the histological assessment of urothelial carcinomas.

Europe PMC ID: 2317652

Vilela et al. 1987. J Pathol. 153(4):365-75. PMID: 3323436.

IHC

Monoclonal antibody to desmosomal glycoprotein 1--a new epithelial marker for diagnostic pathology.

Europe PMC ID: 3323436


Add a reference

References: 10 entries

Maruani et al. 2008. Am J Clin Pathol. 130(3):369-74. PMID: 18701409.

IHC

Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome.

A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen.

Vilela et al. 1995. J Cell Sci. 108 ( Pt 4):1743-50. PMID: 7615689.

IF WB

Harada et al. 1992. Int J Oral Maxillofac Surg. 21(6):346-9. PMID: 1282923.

IHC

Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential.

Conn et al. 1990. Br J Urol. 65(2):176-80. PMID: 2317652.

IHC

Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein 1. Its role in the histological assessment of urothelial carcinomas.

Vilela et al. 1987. J Pathol. 153(4):365-75. PMID: 3323436.

IHC

Monoclonal antibody to desmosomal glycoprotein 1--a new epithelial marker for diagnostic pathology.


Add a reference


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