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Monoclonal Antibodies

Anti-MUC5B [EU-MUC5Ba]

Invented by Prof Dallas Swallow from GEE UCL
Invented at University College London
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Adapted from van Leeuwen et al. 2018. Oral Dis; 24(6):972-982. PMID: 29637662. Figure. Coomassie Brilliant Blue (CBB)- and Periodic Acid- Schiff (PAS)- stained gel and Western blots for MUC5B and albumin of one representative patient.
Adapted from Lachowicz-Scroggins et al. 2016. Am J Respir Crit Care Med; 194(10):1296-1299. PMID: 27845589. Figure. Representative images from immunofluorescence of a sputum smear from a donor with asthma shows that MUC5AC and MUC5B exist in discrete locations in the mucus gel (F). This is especially apparent in clipping plane images that reveal three-dimensional structures (G). Scale bar represents 25 μm. RLU = relative luminescence units.
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Catalogue Number 151702
Applications ELISA IHC WB
Antigen/Gene or Protein Targets MUC5B (Non glycosylated domain of mucin MUC5B/salivary mucin MG1)
Synonyms AKA: EU-MUC5Ba - [6F10-E4]
Reactivity Human
Relevance This antibody can be used to detect respiratory and salivary mucins in clinical and experimental material.
Host Mouse
Immunogen KLH conjugated peptide RNREQVGKF in 4 of the cysteine domains of the tandem repeat region was used to immunise Balb/c female mice.
Subclass IgG1 kappa
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions Cell were grown in IMDM medium containing hypoxanthine, aminopterin, thymidine, 20% FCS and 10% Domadrive.
Strain Balb/c
Notes Myeloma cell line HPRT-deficient SP2/0
Research Area Cell Structure and Motility

References

There are 4 reference entries for this reagent.

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References: 4 entries

van Leeuwen et al. 2018. Oral Dis. 24(6):972-982. PMID: 29637662.

WB

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Lachowicz-Scroggins et al. 2016. Am J Respir Crit Care Med. 194(10):1296-1299. PMID: 27845589.

ELISA IHC

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Rousseau et al. 2003. Hybrid Hybridomics. 22(5):293-9. PMID: 14678646.

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New monoclonal antibodies to non-glycosylated domains of the secreted mucins MUC5B and MUC7.

Europe PMC ID: 14678646

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References: 4 entries

van Leeuwen et al. 2018. Oral Dis. 24(6):972-982. PMID: 29637662.

WB

View  

Lachowicz-Scroggins et al. 2016. Am J Respir Crit Care Med. 194(10):1296-1299. PMID: 27845589.

ELISA IHC

View  

Rousseau et al. 2003. Hybrid Hybridomics. 22(5):293-9. PMID: 14678646.

View  

New monoclonal antibodies to non-glycosylated domains of the secreted mucins MUC5B and MUC7.

View  

Add a reference

Inventor Information