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Anti-cROS [7-1B]

Invented by Dr Al Charest at Tufts University

Info

Catalogue Number 151668
Applications FACS IF IP Fn WB
Antigen/Gene or Protein Targets cROS
Reactivity Human
Relevance c-ROS is a proto-oncogene tyrosine kinase, that is highly-expressed in a variety of tumour cell lines and belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. It is a type I integral membrane protein and may function as a growth or differentiation factor receptor. The c-ROS gene promoter region has been identified and characterized and it has been shown that the ectopic expression of c-ROS in tumors is tied to hypomethylation of a CpG island in the c-ROS promoter.
Host Mouse
Immunogen Extracellular portion of ROS amino acid 1-285 fused to Fc, transiently expressed in 293 cells and purified using PtnA column chromatography.
Subclass IgG1
Positive Control Cells transiently expressing human cROS, mouse cells expressing human c-ROS
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 20% FCS low IgG
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

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