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Anti-cROS [5-4E]

Invented by Dr Al Charest at Tufts University

Info

Catalogue Number 151667
Applications FACS IF IP Fn WB
Antigen/Gene or Protein Targets cROS
Reactivity Human
Relevance c-ROS is a proto-oncogene tyrosine kinase, that is highly-expressed in a variety of tumour cell lines and belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. It is a type I integral membrane protein and may function as a growth or differentiation factor receptor. The c-ROS gene promoter region has been identified and characterized and it has been shown that the ectopic expression of c-ROS in tumors is tied to hypomethylation of a CpG island in the c-ROS promoter.
Host Mouse
Immunogen Extracellular portion of ROS amino acid 1-285 fused to Fc, transiently expressed in 293 cells and purified using PtnA column chromatography.
Subclass IgG1
Positive Control Cells transiently expressing human cROS, mouse cells expressing human cROS
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 20% FCS low IgG
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

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