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PDVC57B Cell Line


Catalogue Number 151630
Antigen/Gene or Protein Targets PDVC57b
Parental Line PDV
Host Mouse
Disease Keywords Carcinoma Squamous Cell
Model Tumour line
Relevance The PDVC57B Cell Line is useful for the study of the progression of carcinogenesis and as a model of relapse after surgery. PDVC57B is syngeneic for C57B1/6 mice and carries a p53 mutation in codon 231, (ATG-GTC) and an A-T tranversion at cod 61 of the H-ras gene. These events appear to be remarkably similar to the sequence of changes seen during tumour development in vivo.
Production Details The transformed PDVB57B was created by treating the PDV cell line with the carcinogen DMBA.
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Drug Discovery & Development, Epigenetics & Nuclear Signalling
Growth/Phenotype Keywords Mouse spindle cell carcinoma, Adherent
Recommended Growing Conditions DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
Cellosaurus ID CVCL_4271

References: 2 entries

Clin Cancer Res. 2002 Jun;8(6):1984-94.PMID: 12060644

Quintanilla et al. 1991. Carcinogenesis. 12(10):1875-81. PMID: 1934268.

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