PDVC57B Cell Line
Invented at Cancer Research UK Glasgow: The Beatson Institute
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 151630 |
| Antigen/Gene or Protein Targets | PDVC57b |
| Parental Line | PDV |
| Host | Mouse |
| Disease Keywords | Carcinoma Squamous Cell |
| Model | Tumour line |
| Relevance | The PDVC57B Cell Line is useful for the study of the progression of carcinogenesis and as a model of relapse after surgery. PDVC57B is syngeneic for C57B1/6 mice and carries a p53 mutation in codon 231, (ATG-GTC) and an A-T tranversion at cod 61 of the H-ras gene. These events appear to be remarkably similar to the sequence of changes seen during tumour development in vivo. |
| Production Details | The transformed PDVB57B was created by treating the PDV cell line with the carcinogen DMBA. |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Drug Discovery & Development, Epigenetics & Nuclear Signalling |
| Growth/Phenotype Keywords | Mouse spindle cell carcinoma, Adherent |
| Recommended Growing Conditions | DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS). |
| Cellosaurus ID | CVCL_4271 |
References: 3 entries
Clin Cancer Res. 2002 Jun;8(6):1984-94.PMID: 12060644
Quintanilla et al. 1991. Carcinogenesis. 12(10):1875-81. PMID: 1934268.
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
Europe PMC ID: 1934268
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References: 3 entries
Clin Cancer Res. 2002 Jun;8(6):1984-94.PMID: 12060644
Quintanilla et al. 1991. Carcinogenesis. 12(10):1875-81. PMID: 1934268.
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
Add a reference
