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Anti-MMP3 [1B4]

Info

Catalogue Number 151620
Applications ELISA IHC IF IP WB
Antigen/Gene or Protein Targets Human matrix metalloproteinase 3 (MMP-3)
Reactivity Human
Relevance Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH
Subclass IgG1
Positive Control IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-3, 400 ng per lane
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Western blot: not reactive with MMP-1, MMP-2, MMP-9
Research Area Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling

References: 5 entries

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.

Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.


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