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|Applications||ELISA IHC IF IP WB|
|Antigen/Gene or Protein Targets||Human matrix metalloproteinase 3 (MMP-3)|
|Relevance||Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.|
|Immunogen||Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH|
|Positive Control||IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-3, 400 ng per lane|
|Notes||Western blot: not reactive with MMP-1, MMP-2, MMP-9|
|Research Area||Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling|
References: 5 entries
Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
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