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Anti-MMP2 [4D3]


Catalogue Number 151619
Applications ELISA IHC IF IP WB
Antigen/Gene or Protein Targets Human matrix metalloproteinase 2 (MMP-2)
Reactivity Human
Relevance MMP2 degrades type IV collagen and plays an important role in menstrual break down, regulation of vascularization, angiogenesis, and inflammatory response. Mutations of MMP2 are associated with Torg-Winchester syndrome.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; TSLGLPPDVQRVD
Subclass IgG1
Positive Control IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-2, 400 ng per lane
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Does not cross react on Western blot: with MMP-1, -9. The antibody reacts with MMP3
Research Area Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

References: 5 entries

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.

Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.

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