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Anti-MMP1 [3B6]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 151618
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Human matrix metalloproteinase 1 (MMP-1)
Reactivity Human
Relevance MMP1 cleaves collagens of types I, II, and III at one site in the helical domain. MMP1 also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; CSSFGFPRTVKH
Subclass IgG1
Positive Control IHC: formalin-fixed, paraffin-embedded colonic adenocarcinomaWestern blot: rhMMP-1, 400 ng per lane
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes (i) no cross-reactivity in immunoblot panel (MMP-2, -3, -9); (ii) staining in antigen-positive wax-imbedded tissues
Research Area Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling

References: 12 entries

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.

Europe PMC ID: 19635101

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Profiling markers of prognosis in colorectal cancer.

Europe PMC ID: 16489072

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.

Europe PMC ID: 15623598

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.

Matrix metalloproteinases and their inhibitors in gastric cancer.

Europe PMC ID: 9824606

Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.

Europe PMC ID: 9771478

Murray et al. 1996. Nat Med. 2(4):461-2. PMID: 8597958.

Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.

Europe PMC ID: 8597958


Add a reference

References: 12 entries

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.

Europe PMC ID: 19635101

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Profiling markers of prognosis in colorectal cancer.

Europe PMC ID: 16489072

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.

Europe PMC ID: 15623598

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.

Matrix metalloproteinases and their inhibitors in gastric cancer.

Europe PMC ID: 9824606

Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.

Europe PMC ID: 9771478

Murray et al. 1996. Nat Med. 2(4):461-2. PMID: 8597958.

Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.

Europe PMC ID: 8597958


Add a reference

References: 12 entries

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Profiling markers of prognosis in colorectal cancer.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.

Matrix metalloproteinases and their inhibitors in gastric cancer.

Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.

Murray et al. 1996. Nat Med. 2(4):461-2. PMID: 8597958.

Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.


Add a reference


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