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Anti-MMP1 [3B6]


Catalogue Number 151618
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Human matrix metalloproteinase 1 (MMP-1)
Reactivity Human
Relevance MMP1 cleaves collagens of types I, II, and III at one site in the helical domain. MMP1 also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; CSSFGFPRTVKH
Subclass IgG1
Positive Control IHC: formalin-fixed, paraffin-embedded colonic adenocarcinomaWestern blot: rhMMP-1, 400 ng per lane
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes (i) no cross-reactivity in immunoblot panel (MMP-2, -3, -9); (ii) staining in antigen-positive wax-imbedded tissues
Research Area Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling

References: 6 entries

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.

Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.

Murray et al. 1996. Nat Med. 2(4):461-2. PMID: 8597958.

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