Anti-Transmembrane protein [3B5/D7]
Invented by Dr Tyson Sharp from Barts Cancer Institute
Invented at University College London
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151610 |
| Applications | ELISA IF IP WB |
| Antigen/Gene or Protein Targets | K15 (putative integral transmembrane protein similar to LMP2A) |
| Reactivity | Human and Virus |
| Relevance | Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities. |
| Host | Mouse |
| Immunogen | Recombinant protein |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 50 (full) to 17 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Apoptosis and Programmed Cell Death, Protein Degradation, Virology |
References: 2 entries
Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170.
K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.
Europe PMC ID: 11752170
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References: 2 entries
Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170.
K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.
Add a reference
