Cat. #151610
Anti-Transmembrane protein [3B5/D7]
Cat. #: 151610
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: K15 (putative integral transmembrane protein similar to LMP2A)
Class: Monoclonal
Application: ELISA ; IF ; IP ; WB
Reactivity: Human ; Virus
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Tyson Sharp
Institute: University College London (UCL)
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Transmembrane protein [3B5/D7]
- Clone: 3B5/D7
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 50 kDa (full) to 17 kDa
- Strain: Balb/c
- Reactivity: Human ; Virus
- Host: Mouse
- Application: ELISA ; IF ; IP ; WB
- Description: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
- Immunogen: Recombinant protein
- Isotype: IgG1
- Myeloma used: P3X63Ag8.653
Target Details
- Target: K15 (putative integral transmembrane protein similar to LMP2A)
- Molecular weight: 50 kDa (full) to 17 kDa
- Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
Applications
- Application: ELISA ; IF ; IP ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Storage conditions: -80° C
- Shipping conditions: Shipping at 4° C
References
- Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170.
- K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.
