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Anti-Transmembrane protein [3B5/D7]


Catalogue Number 151610
Applications ELISA IF IP WB
Antigen/Gene or Protein Targets K15 (putative integral transmembrane protein similar to LMP2A)
Reactivity Human and Virus
Relevance Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
Host Mouse
Immunogen Recombinant protein
Subclass IgG1
Molecular Weight (kDa) 50 (full) to 17
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Apoptosis and Programmed Cell Death, Protein Degradation, Virology

References: 1 entry

Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170.

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