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Anti-Phospho RacGAP1 (Ser157), Polyclonal [pS157 HsCyk-4]


Catalogue Number 151587
Applications IF IP WB
Antigen/Gene or Protein Targets pS157 HsCyk-4 (MgcRacGAP and RacGAP1)
Synonyms Cyk-4
Reactivity Human, Mouse and Rat
Relevance HsCyk-4 (or MgcRacGAP) is a subunit of the centralspindlin, and contains a GTPase activator protein (GAP) domain and directly interacts with the GTP exchange factor (GEF) Ect2, and both HsCyk-4 and Ect2 are essential for equatorial recruitment of the RhoA GTPase, the master regulator of actomyosin dynamics during cytokinesis. Plk1 binds and directly phosphorylates the HsCyk-4.
Host Rabbit
Immunogen Synthetic phospho-peptide ILSDI-pS-FDKTD corresponding to HsCyk-4 aa 152-162 (human)
Notes The immunogen is 100% conserved from human to mouse to rat; and the phosphorylation of Ser157 has been shown in human cells but not in mouse and rat.

Western blot 1:1000
Immunofluorescence 1:500
Positive Control Western blot on mitotic HeLa cell lysates (e.g. nocodazole arrested cells)
Research Area Cell Cycle

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