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Anti-CD44v3 [3G5]

Info

Catalogue Number 151575
Applications ELISA FACS IHC IP WB
Antigen/Gene or Protein Targets CD44v3-10-Fc
Synonyms CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1
Reactivity Human
Relevance Monoclonal antibody directed against a marker of tumour metastasis.

Background and Research Application
CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. CD44 is expressed on multiple cell types and is involved in multiple functions including cell-cell interactions and cell-extracellular matrix binding. The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications.

This antibody recognizes an epitope encoded by exon v3 on the variant portion of human CD44.
Host Mouse
Immunogen Human chimeric fusion protein CD44v3-10-Fc
Immunogen UniProt ID P16070
Subclass IgG2b
Myeloma Used Sp2/0-Ag14
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
It has been reported that CD44v3 and CD44v6 are associated with tumour progression and metastasis in many types of tumours, including breast, colon, lung, renal, skin, and ovarian cancers.

Concentration
1mg/ml as standard
Research Area Adhesion, Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology

References

There are 5 reference entries for this reagent.

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References: 5 entries

Yoo et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27872288.

ELISA WB

MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis.

Europe PMC ID: 27872288

Liu et al. 2014. Asian Pac J Cancer Prev. 15(12):5049-53. PMID: 24998585.

Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.

Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.

Europe PMC ID: 7519124


Add a reference

References: 5 entries

Yoo et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27872288.

ELISA WB

MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis.

Liu et al. 2014. Asian Pac J Cancer Prev. 15(12):5049-53. PMID: 24998585.

Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.

Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

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