Anti-CD44v3 [3G5]
Invented at University of Oxford
- Datasheet
- References (5)
- Inventor Info
Info
| Catalogue Number | 151575 |
| Applications | ELISA FACS IHC IP WB |
| Antigen/Gene or Protein Targets | CD44v3-10-Fc |
| Synonyms | CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1 |
| Reactivity | Human |
| Relevance |
Monoclonal antibody directed against a marker of tumour metastasis. Background and Research Application CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. CD44 is expressed on multiple cell types and is involved in multiple functions including cell-cell interactions and cell-extracellular matrix binding. The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications. This antibody recognizes an epitope encoded by exon v3 on the variant portion of human CD44. |
| Host | Mouse |
| Immunogen | Human chimeric fusion protein CD44v3-10-Fc |
| Immunogen UniProt ID | P16070 |
| Subclass | IgG2b |
| Myeloma Used | Sp2/0-Ag14 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest It has been reported that CD44v3 and CD44v6 are associated with tumour progression and metastasis in many types of tumours, including breast, colon, lung, renal, skin, and ovarian cancers. Concentration 1mg/ml as standard |
| Research Area | Adhesion, Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology |
References: 5 entries
Yoo et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27872288.
ELISA WB
MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis.
Europe PMC ID: 27872288
Liu et al. 2014. Asian Pac J Cancer Prev. 15(12):5049-53. PMID: 24998585.
Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.
Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.
Europe PMC ID: 7519124
Add a reference
References: 5 entries
Yoo et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27872288.
ELISA WB
MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis.
Liu et al. 2014. Asian Pac J Cancer Prev. 15(12):5049-53. PMID: 24998585.
Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.
Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.
Add a reference
