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Anti-CD44v3 [2C5]

Info

Catalogue Number 151572
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets CD44v3-10-Fc
Synonyms CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1
Reactivity Human
Relevance CD44H, also called CD44s, refers to the standard form of CD44 without variable exons. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. CD44 belongs to a family of cell surface glycoproteins that bind to hyaluronan. CD44H is involved in cell-cell and cellextracellular matrix adhesion.
Host Mouse
Immunogen Human chimeric fusion protein
Subclass IgG2a
Recommended Growing Conditions DMEM + 10% FBS
Notes This antibody recognizes all CD44 protein isoforms.
Research Area Adhesion, Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology

References: 14 entries

Nagano et al. 2004. Cancer Sci. 95(12):930-5. PMID: 15596040.

Lynch et al. 2004. Nat Rev Immunol. 4(12):931-40. PMID: 15573128.

Consequences of regulated pre-mRNA splicing in the immune system.

Europe PMC ID: 15573128

Mechanism and biological significance of CD44 cleavage.

Europe PMC ID: 15596040

Murakami et al. 2003. Oncogene. 22(10):1511-6. PMID: 12629514.

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Europe PMC ID: 12629514

Ponta et al. 2003. Nat Rev Mol Cell Biol. 4(1):33-45. PMID: 12511867.

CD44: from adhesion molecules to signalling regulators.

Europe PMC ID: 12511867

Yu et al. 1996. J Biol Chem. 271(34):20603-7. PMID: 8702806.

A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44.

Europe PMC ID: 8702806

Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.

Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.

Europe PMC ID: 7519124

Screaton et al. 1992. Proc Natl Acad Sci U S A. 89(24):12160-4. PMID: 1465456.

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

Europe PMC ID: 1465456


Add a reference

References: 14 entries

Nagano et al. 2004. Cancer Sci. 95(12):930-5. PMID: 15596040.

Lynch et al. 2004. Nat Rev Immunol. 4(12):931-40. PMID: 15573128.

Consequences of regulated pre-mRNA splicing in the immune system.

Europe PMC ID: 15573128

Mechanism and biological significance of CD44 cleavage.

Europe PMC ID: 15596040

Murakami et al. 2003. Oncogene. 22(10):1511-6. PMID: 12629514.

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Europe PMC ID: 12629514

Ponta et al. 2003. Nat Rev Mol Cell Biol. 4(1):33-45. PMID: 12511867.

CD44: from adhesion molecules to signalling regulators.

Europe PMC ID: 12511867

Yu et al. 1996. J Biol Chem. 271(34):20603-7. PMID: 8702806.

A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44.

Europe PMC ID: 8702806

Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.

Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.

Europe PMC ID: 7519124

Screaton et al. 1992. Proc Natl Acad Sci U S A. 89(24):12160-4. PMID: 1465456.

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

Europe PMC ID: 1465456


Add a reference

References: 14 entries

Nagano et al. 2004. Cancer Sci. 95(12):930-5. PMID: 15596040.

Lynch et al. 2004. Nat Rev Immunol. 4(12):931-40. PMID: 15573128.

Consequences of regulated pre-mRNA splicing in the immune system.

Mechanism and biological significance of CD44 cleavage.

Murakami et al. 2003. Oncogene. 22(10):1511-6. PMID: 12629514.

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Ponta et al. 2003. Nat Rev Mol Cell Biol. 4(1):33-45. PMID: 12511867.

CD44: from adhesion molecules to signalling regulators.

Yu et al. 1996. J Biol Chem. 271(34):20603-7. PMID: 8702806.

A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44.

Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.

Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.

Screaton et al. 1992. Proc Natl Acad Sci U S A. 89(24):12160-4. PMID: 1465456.

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.


Add a reference


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