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Anti-TFF1 [PS2GE2]


Catalogue Number 151569
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Trefoil factor 1 (TFF1), also known as pS2
Synonyms BCEI, Breast Cancer Estrogen Inducible Protein, Gastrointestinal Trefoil Protein, Gastrointestinal trefoil protein pS2, HP1A, HPS2, pNR2, TFF1, Trefoil Factor 1
Human Entrez Gene ID 7031
Human SwissProt P04155
Human Unigene 162807
Human Gene Symbol TFF1
Human Chromosome Location 16p11.2
Reactivity Human
Relevance pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
Host Mouse
Immunogen A synthetic peptide of 28 amino acid residues from the C-terminus of human pS2 protein
Subclass IgG1 kappa
Positive Control Normal stomach, breast or ovarian carcinoma
Molecular Weight (kDa) 6.5
Notes Cellular Localization: Cytoplasmic
Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml); Immunohistology (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Research Area Cancer, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling

References: 1 entry

Williams R, et al. 1996. Hum Pathol.(12):1259-66.PMID: 8958295

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