Anti-TFF1 [PS2GE1]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151568 |
| Applications | IHC IP |
| Antigen/Gene or Protein Targets | Trefoil factor 1 (TFF1) also known as pS2/pNR2 Estrogen-regulated protein Ab2 |
| Reactivity | Human |
| Relevance | pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours. |
| Host | Mouse |
| Immunogen | A synthetic 31-mer peptide from the C-terminus of human pS2 protein |
| Positive Control | Normal stomach or breast carcinoma |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 6.5 |
| Notes | Immunohistochemistry (formalin fixed paraffin embedded): use at a concentration of 2 - 4µg/ml for 30 minutes at RT. |
| Research Area | Cancer, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling |
References: 2 entries
Williams et al. 1996. Hum Pathol. 27(12):1259-66. PMID: 8958295.
Characterization of monoclonal antibodies raised to C-terminal peptides of pS2: a major trefoil peptide and motility factor expressed in adenocarcinomas and regions of mucosal injury.
Europe PMC ID: 8958295
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References: 2 entries
Williams et al. 1996. Hum Pathol. 27(12):1259-66. PMID: 8958295.
Characterization of monoclonal antibodies raised to C-terminal peptides of pS2: a major trefoil peptide and motility factor expressed in adenocarcinomas and regions of mucosal injury.
Add a reference
