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Anti-TFF1 [PS2GE1]


Catalogue Number 151568
Applications IHC IP
Antigen/Gene or Protein Targets Trefoil factor 1 (TFF1) also known as pS2/pNR2 Estrogen-regulated protein Ab2
Reactivity Human
Relevance pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
Host Mouse
Immunogen A synthetic 31-mer peptide from the C-terminus of human pS2 protein
Subclass IgG1
Positive Control Normal stomach or breast carcinoma
Molecular Weight (kDa) 6.5
Notes Immunohistochemistry (formalin fixed paraffin embedded): use at a concentration of 2 - 4µg/ml for 30 minutes at RT.
Research Area Cancer, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling

References: 1 entry

Williams et al. 1996. Hum Pathol. 27(12):1259-66. PMID: 8958295.

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