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K14dNb Mouse

Invented by Prof Fiona Watt at King's College London

Info

Catalogue Number 151565
Antigen/Gene or Protein Targets Beta-catenin N-terminal truncation (deltaNbeta-catenin) fused with estrogen receptor (ER)
Disease Keywords Cancer; colorectal cancer; melanoma; telogen effluvium (hair loss);
Relevance In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation;
Production Details A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Conditional Yes
Conditional Description Conditional expression of deltaNbeta-cateninER under Keratin 14 promoter giving tissue-specific epidermal expression.
Growth/Phenotype Keywords Skin abnormalities (hair follicle);
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Genetic Studies Tools, Neurobiology, Stem Cell Biology

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