K14dNLef1 Mouse
Invented by Prof Fiona Watt from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151564 |
| Antigen/Gene or Protein Targets | Lef1 N-terminal mutant (constituitive transcirptional activity) |
| Disease Keywords | Cancer; sebaceous adenoma; sebeoma; squamous papilloma; telogen effluvium; |
| Relevance | In vivo study of Lef1 activity in skin; model for hair growth & follicle formation; disease model for skin tumour formation (sebaceous adenoma, sebeoma, squamous papilloma) |
| Production Details | A deltaNLef1 transgene vector, containing an N-terminally deleted mouse Lef1 cDNA under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines. |
| Conditional | Yes |
| Conditional Description | Conditional expression of deltaN-Lef1 under Keratin 14 promoter giving tissue-specific epidermal expression. |
| Growth/Phenotype Keywords | Tumourigenesis (skin); skin abnormalities (hair follicle, sebaceous gland) |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Developmental Biology, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Stem Cell Biology |
References: 2 entries
Niemann et al. 2002. Development. 129(1):95-109. PMID: 11782404.
Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
Europe PMC ID: 11782404
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References: 2 entries
Niemann et al. 2002. Development. 129(1):95-109. PMID: 11782404.
Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours.
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