JamC -/- Mouse
Invented by Prof Ralf H. Adams from Max Planck Society
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151562 |
| Antigen/Gene or Protein Targets | Junctional adhesion molecule-C (JAM-C) |
| Disease Keywords | Neuropathy; inflammatory disease; |
| Relevance | In vivo study of JAM-C knockout; in vivo study of spermiogenesis; in vivo study of neuronal networks and integrity |
| Production Details | A JamC targeting vector, containing loxP flanked exons 4, 5, and a cDNA encoding exons 6 to 9, an exon 4 - reporter fusion, and a frt flanked resistance cassette, was injected into E14 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into C57BL6 blastocysts. Chimeric offspring were mated to C57BL6 mice, and floxed JamC lines maintained on a mixed 129/C57BL6 background. Floxed JamC mice were crossed with Cre expressing mice to generate heterozygous JamC+/- mice. Heterozygous JamC+/- mice were interbred to generate JamC-/- mice. |
| Conditional | No |
| Growth/Phenotype Keywords | Reproductive abnormalities (male); neurological abnormalities (motor function); |
| Mouse Genetic Background/Cross History | 129/C57BL/6 |
| Zygosity | Heterozygous |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Neurobiology |
| Notes | Mice are maintained as heterozygotes (JamC+/-) to permit breeding (due to male fertility defects in JamC-/- mice). |
References: 2 entries
Gliki et al. 2004. Nature. 431(7006):320-4. PMID: 15372036.
Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C.
Europe PMC ID: 15372036
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References: 2 entries
Gliki et al. 2004. Nature. 431(7006):320-4. PMID: 15372036.
Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C.
Add a reference
