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JamC -/- Mouse


Catalogue Number 151562
Antigen/Gene or Protein Targets Junctional adhesion molecule-C (JAM-C)
Disease Keywords Neuropathy; inflammatory disease;
Relevance In vivo study of JAM-C knockout; in vivo study of spermiogenesis; in vivo study of neuronal networks and integrity
Production Details A JamC targeting vector, containing loxP flanked exons 4, 5, and a cDNA encoding exons 6 to 9, an exon 4 - reporter fusion, and a frt flanked resistance cassette, was injected into E14 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into C57BL6 blastocysts. Chimeric offspring were mated to C57BL6 mice, and floxed JamC lines maintained on a mixed 129/C57BL6 background. Floxed JamC mice were crossed with Cre expressing mice to generate heterozygous JamC+/- mice. Heterozygous JamC+/- mice were interbred to generate JamC-/- mice.
Conditional No
Growth/Phenotype Keywords Reproductive abnormalities (male); neurological abnormalities (motor function);
Mouse Genetic Background/Cross History 129/C57BL/6
Zygosity Heterozygous
Research Area Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Neurobiology
Notes Mice are maintained as heterozygotes (JamC+/-) to permit breeding (due to male fertility defects in JamC-/- mice).

References: 1 entry

Gliki et al. 2004. Nature. 431(7006):320-4. PMID: 15372036.

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