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|Antigen/Gene or Protein Targets||Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb)|
|Disease Keywords||Gastric cancer|
|Relevance||A mouse model with epidermal FgfR 2b expression knocked out. The mouse lives a normal life span but has altered hair morphology. It has a tendency to develop skin papillomas spontaneously and development of these can be accelerated greatly by use of a carcinogen.|
|Production Details||Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background.|
|Conditional Description||Fgfr2bflox/flox mouse crossed with K5-Cre mouse (tissue-specific Cre expression in skin) giving tissue-specific knockout of FGFR2 IIIb isoform in skin.|
|Growth/Phenotype Keywords||Skin abnormalities, Tumourigenesis|
|Research Area||Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology|
The K5-R2b-null mouse is an ideal tool in the study of the tumour suppressive role of the FGFR2 IIIb isoform in skin tumourigenesis.
Skin tumours develop in K5-R2b-null mice following two-step carcinogen treatment with DMBA and TPA.
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