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MEF UNG KO Cell Line


Catalogue Number 151559
Antigen/Gene or Protein Targets Uracil-DNA Glycosylase (UNG)
Host Mouse
Tissue Embryo
Disease Keywords Cancer, B cell lymphoma
Model Knock-Out
Relevance The MEF UNG KO Cell Line is a tool for in vivo study of the function of UNG and the effects of DNA mismatch during DNA synthesis. UNG encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway.
Production Details Primary MEFs were prepared from embryos, and permanent cell lines established from transformed clones arising spontaneously after repeated passage in culture, by standard procedures
Research Area DNA Damage and Repair
Recommended Growing Conditions DMEM:F12 (1:1) + 10% FCS.

References: 1 entry

Nilsen et al. 2003. Oncogene. 22(35):5381-6. PMID: 12934097.

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