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UNG Mouse


Catalogue Number 151556
Antigen/Gene or Protein Targets Uracil-DNA Glycosylase (UNG)
Disease Keywords Cancer, B cell lymphoma
Relevance In vivo study of UNG knockout and DNA mismatch mutation during DNA synthesis. Mice develop B cell lymphoma and are abnormally defective in their immune response. There are also mouse embryonic fibroblasts from this line available.
Production Details A ung targeting vector, replacing exon 4 with a resistance cassette, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into C57BL6 blastocysts. Chimeric mice were mated with C57BL6 mice to generate heterozygotes. Heterozygous mice were crossed to generate homozygous Ung-/- mice.
Conditional No
Mouse Genetic Background/Cross History 129/C57BL/6
Zygosity Homozygous
Research Area Cancer, DNA Damage and Repair, Genetic Studies Tools, Immunology

References: 1 entry

Nilsen et al. 2003. Oncogene. 22(35):5381-6. PMID: 12934097.

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