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MUC1 Mouse


Catalogue Number 151555
Antigen/Gene or Protein Targets Human MUC1 (mucin-like protein 1) / PEM (polymorphic epithelial mucin)
Disease Keywords Cancer; adenocarcinoma; drug metabolism & toxicity
Synonyms ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
Relevance Model for preclinical study of anti-MUC1 vaccines/immunotherapies;
Production Details A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes.
Conditional Description Genomic fragment containing complete MUC1 gene and promoter region, enabling tissue-specific MUC1 expression pattern.
Mouse Genetic Background/Cross History CBA/C57BL/6 or BALBc or C57
Zygosity Homozygous
Research Area Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Genetic Studies Tools
Notes Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.

References: 1 entry

Peat et al. 1992. Cancer Res. 52(7):1954-60. PMID: 1372533.

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