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|Antigen/Gene or Protein Targets||Elk4 / SAP-1|
|Disease Keywords||Castleman disease;|
|Relevance||In vivo study of SAP-1 knockout; in vivo study of positive T cell selection & development|
|Production Details||An Elk4 targeting vector, containing a resistance cassette inserted between exons 1 and 4, was transfected into 129 ES cells. Properly targeted ES cells containing a homologus recombination event were selected, cloned and injected into blastocysts. Chimeric offspring were backcrossed to establish heterozygous lines, and interbred to establish homozygous mice.|
|Growth/Phenotype Keywords||Immune abnormalities (T cell development);|
|Research Area||Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology|
The SAP-1 mouse demonstrate a phenotype analogous to mutlicentric Castleman disease when maintained in non-sterile housing.
SAP-1 mice exhibit abnormalities in T cell populations, resulting from abnormal negative selection during T cell development.
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