SAP1 Mouse
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151554 |
| Antigen/Gene or Protein Targets | Elk4 / SAP-1 |
| Disease Keywords | Castleman disease; |
| Relevance | In vivo study of SAP-1 knockout; in vivo study of positive T cell selection & development |
| Production Details | An Elk4 targeting vector, containing a resistance cassette inserted between exons 1 and 4, was transfected into 129 ES cells. Properly targeted ES cells containing a homologus recombination event were selected, cloned and injected into blastocysts. Chimeric offspring were backcrossed to establish heterozygous lines, and interbred to establish homozygous mice. |
| Conditional | No |
| Growth/Phenotype Keywords | Immune abnormalities (T cell development); |
| Research Area | Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology |
| Notes |
The SAP-1 mouse demonstrate a phenotype analogous to mutlicentric Castleman disease when maintained in non-sterile housing. SAP-1 mice exhibit abnormalities in T cell populations, resulting from abnormal negative selection during T cell development. |
References: 2 entries
Costello et al. 2004. Nat Immunol. 5(3):289-98. PMID: 14770179.
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
Europe PMC ID: 14770179
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References: 2 entries
Costello et al. 2004. Nat Immunol. 5(3):289-98. PMID: 14770179.
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
Add a reference
