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LFA1 -/- Mouse


Catalogue Number 151552
Antigen/Gene or Protein Targets Lymphocyte Function-associated Antigen-1 (LFA1)
Disease Keywords Inflammatory disease;
Synonyms LFA-1, Integrin beta-2, Complement receptor C3 subunit beta, CD18
Model Knock-Out
Relevance In vivo study of LFA-1 knockout; in vivo study of inflammation and leukocyte recruitment;
Production Details An LFA-1 targeting vector, containing a resistance cassette inserted into exon 2, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned and injected into C57BL6 blastocysts. Chimeric offspring were backcrossed to establish heterozygotes. LFA+/- mice were interbred to establish LFA-/- homozygotes.
Conditional No
Strain C57BL/6
Research Area Genetic Studies Tools, Immunology

References: 2 entries

Henderson et al. 2001. J Exp Med. 194(2):219-26. PMID: 11457896.

Berlin-Rufenach et al. 1999. J Exp Med. 189(9):1467-78. PMID: 10224287.

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