LFA1 -/- Mouse
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151552 |
| Antigen/Gene or Protein Targets | Lymphocyte Function-associated Antigen-1 (LFA1) |
| Disease Keywords | Inflammatory disease; |
| Synonyms | LFA-1, Integrin beta-2, Complement receptor C3 subunit beta, CD18 |
| Model | Knock-Out |
| Relevance | In vivo study of LFA-1 knockout; in vivo study of inflammation and leukocyte recruitment; |
| Production Details | An LFA-1 targeting vector, containing a resistance cassette inserted into exon 2, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned and injected into C57BL6 blastocysts. Chimeric offspring were backcrossed to establish heterozygotes. LFA+/- mice were interbred to establish LFA-/- homozygotes. |
| Conditional | No |
| Strain | C57BL/6 |
| Research Area | Genetic Studies Tools, Immunology |
References: 4 entries
Henderson et al. 2001. J Exp Med. 194(2):219-26. PMID: 11457896.
The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils.
Europe PMC ID: 11457896
Berlin-Rufenach et al. 1999. J Exp Med. 189(9):1467-78. PMID: 10224287.
Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice.
Europe PMC ID: 10224287
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References: 4 entries
Henderson et al. 2001. J Exp Med. 194(2):219-26. PMID: 11457896.
The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils.
Berlin-Rufenach et al. 1999. J Exp Med. 189(9):1467-78. PMID: 10224287.
Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice.
Add a reference
