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Anti-SNAIL1 [20C8]


Catalogue Number 151548
Applications ELISA IHC IF IP WB
Antigen/Gene or Protein Targets SNAIL1
Reactivity Human
Relevance The Snail superfamily are zinc finger transcription factors. Overexpression of Snail1 can lead to cells undergoing EMT (epithelial to mesenchymal transition). This is achieved as Snail1 represses expression of E-cadherin, desmoplakin, muc-1, cytokeratin18 while enhances expression of vimentin and fibronectin. Snail1 therefore has a strong association with metastatic disease.
Host Mouse
Immunogen Human Snail 1 recombinant protein
Subclass IgG2a kappa
Positive Control MDAMB-453; MDAMB-435; MDAMB-231; A375
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling

References: 3 entries

Tuhkanen et al. 2009. BMC Cancer. 9:289. PMID: 19695091.

Vincent et al. 2009. Nat Cell Biol. 11(8):943-50. PMID: 19597490.

Francí et al. 2006. Oncogene. 25(37):5134-44. PMID: 16568079.

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