Anti-RAET1E [RAET1E 119/6]
Invented at University of Cambridge
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151542 |
| Applications | ELISA FACS IF IP Fn WB |
| Antigen/Gene or Protein Targets | RAET1E |
| Reactivity | Human |
| Relevance | RAET1E (retinoic acid early transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a functional ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines. |
| Host | Mouse |
| Immunogen | Recombinant His-tagged protein to human extra-cellular domain of RAET1E produced in E.coli (33-227) with a N terminal 6x His tag. |
| Positive Control | Stable RAET1E cell line |
| Subclass | IgG1 kappa |
| Research Area | Immunology |
References: 6 entries
Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.
RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.
Europe PMC ID: 17470428
Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.
Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.
Europe PMC ID: 15240696
Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.
ULBP4 is a novel ligand for human NKG2D.
Europe PMC ID: 12732206
Add a reference
References: 6 entries
Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.
RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.
Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.
Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.
Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.
ULBP4 is a novel ligand for human NKG2D.
Add a reference
