- References (2)
- Inventor Info
|Applications||IHC IF WB|
|Antigen/Gene or Protein Targets||Connexin 32 (Cx32 or ß1)|
|Reactivity||Chicken, Human, Mouse and Rat|
Monoclonal antibody which detects connexin 32, linked to Charcot-Marie-Tooth disease.
Background and Research Application
Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junctions are essential for various physiological processes, including coordinated depolarization of cardiac muscle, proper embryonic development, and the conducted response in microvasculature. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.
Mutations in connexin 32 are linked to Charcot-Marie-Tooth disease X-linked type 1 (CMTX1), the most commonly inherited disorder of the peripheral nervous system.
|Immunogen||The peptide, LEGHGDPLHLEE, was coupled at the C-terminal end to bovine thyroglobulin at a final molar ratio peptide:thyroglobulin of 40–60:1.|
|Immunogen UniProt ID||P08034|
|Positive Control||Heart & liver tissue from 6 week old mice|
|Molecular Weight (kDa)||46|
|Recommended Growing Conditions||RPMI 1640 + 10-20% FBS + glutamine (2mM)|
Purified using multi-step affinity chromatography with protein A.
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.
Points of Interest
Connexin 32 gene has been mapped to Xq13.1. It consists of two exons and encodes a gap junction protein containing four transmembrane domains.
1mg/ml as standard
|Research Area||Cell Signaling & Signal Transduction, Neurobiology|
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