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|Applications||IHC IF WB|
|Antigen/Gene or Protein Targets||Connexin 43 (Cx43 or α1)|
|Relevance||Connexins are a large family of proteins which form gap junctions. Gap junctions are cell membrane structures that facilitate direct cell-cell communication. Gap junction communication has been implicated in the patterning and development of vertebrate embryos. Individual connexins show complex spatial and temporal variation in expression patterns. This variation contributes to the control of intercellular signalling.|
|Immunogen||The peptide, EIKKFKYGIEEH, was coupled at the C-terminal end to bovine thyroglobulin at a final molar ratio peptide:thyroglobulin of 40–60:1.|
|Positive Control||Heart & liver tissue from 6 week old mice; Heart tissue expresses predominantly Cx43|
|Recommended Growing Conditions||RPMI 1640 + 10-20% FBS + glutamine (2mM)|
|Research Area||Cell Signaling & Signal Transduction, Neurobiology|
References: 4 entries
Gorbe et al. 2007. Exp Cell Res. 313(6):1135-48. PMID: 17331498.
Pearson et al. 2005. J Neurosci. 25(46):10803-14. PMID: 16291954.
Saitongdee et al. 2004. J Histochem Cytochem. 52(5):603-15. PMID: 15100238.
Wright et al. 2001. Reproduction. 121(1):77-88. PMID: 11226030.
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